Evidence map›Paper›PMID 40778117›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Artemisinin Partial Resistance Mutations in Zanzibar and Tanzania Suggest Regional Spread and African Origins, 2023.

Sean V Connelly, Julia G Muller, Mohamed Ali, Billy E Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L Thwai, Jacob M Sadler, Jacob Marglous, Abebe A Fola and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Sean V ConnellyMD-PhD Program, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-7330-7340
Julia G MullerDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0009-0962-5975
Mohamed AliZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Billy E NgasalaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-9300-7719
Wahida HassanZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.ORCID 0009-0004-0452-751X
Bakari MohamedZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Kyaw L ThwaiDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jacob M SadlerDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0001-6430-608X
Jacob MarglousDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.
Abebe A FolaDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0001-5392-2859
Abdallah ZachariaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-9380-6158
Shija J ShijaZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Safia MohammedZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Msolo C DominickDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Hamza SaidDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Editruda E PeterDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Melic OdasDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Isaack J RuthaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Mwanaidi NwangeDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Karamoko NaireDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-7406-9508
Shazia Ruybal-PesántezMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.ORCID 0000-0002-0495-179X
Robert VerityMRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.ORCID 0000-0002-3902-8567
Rebecca CrudaleDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-0789-4196
Varun GoelDepartment of Geography, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-2933-427X
Barbara B CholoiDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anders BjörkmanDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-8882-130X
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-6899-8204
Jessica T LinDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4516-723X
Jonathan J JulianoDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0591-0850

Funding

Importation and transmission of malaria in Zanzibar: a case study for eliminationR01AI155730 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J, LIN, JESSICA · 2021 to 2024
$2.8M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hostsF30AI183592 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sean Connelly · 2024 to 2026
$130k
NIAID NIH HHS F30 AI183592NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI155730
6 · The paper itself

Abstract

Artemisinin partial resistance (ART-R), driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to ART-R spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected in 2022-2024. K13 mutations (P441L, A675V) were found in 2/1440 Zanzibar participants and 6/3762 (R561H, P441L) in mainland Tanzania. K13 mutations appear to be of African origin and spreading regionally based on whole genome sequencing data. Frequent parasite importation appears to maintain partner drug mutation frequencies similar to the mainland, where artemether-lumefantrine selects for mutations favoring artesunate-amodiaquine sensitivity. Ongoing molecular surveillance remains essential to track these patterns.

Indexed as

antimalarial resistanceartemisininfalciparummalariaPlasmodiumZanzibar

Identifiers

PMID40778117
PMCPMC12330450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.