Evidence map›Paper›PMID 40778050›Full record

ArticleFrontiers in urology2023

The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study.

Bagdagul Aksu, Alberto Caldas Afonso, Ipek Akil, Harika Alpay, Bahriye Atmis, Ozlem Aydog, Sevcan Bakkaloglu, Aysun Karabay Bayazıt, Meral Torun Bayram, Ilmay Bilge and 53 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors.

Bagdagul AksuDepartment of Pediatrics Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Türkiye.
Alberto Caldas AfonsoDivision of Pediatric Nephrology, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ipek AkilDivision of Pediatric Nephrology, Faculty of Medicine, Celal Bayar University, Manisa, Türkiye.
Harika AlpayDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Bahriye AtmisDivision of Pediatric Nephrology, Erzurum Training and Research Hospital, University of Health Sciences, Erzurum, Türkiye.
Ozlem AydogDivision of Pediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Türkiye.
Sevcan BakkalogluDivision of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Aysun Karabay BayazıtDivision of Pediatric Nephrology, Faculty of Medicine, Cukurova University, Adana, Türkiye.
Meral Torun BayramDivision of Pediatric Nephrology, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
Ilmay BilgeDivision of Pediatric Nephrology, School of Medicine, Koc University, Istanbul, Türkiye.
Ipek Kaplan BulutDivision of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Türkiye.
Ayse Pinar Goksu CetinkayaDivision of Pediatric Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Elif ComakDivision of Pediatric Nephrology, Faculty of Medicine, Akdeniz University, Antalya, Türkiye.
Belde Kasap DemirDivision of Pediatric Nephrology, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Türkiye.
Nida DincelDivision of Pediatric Nephrology, Dr. Behcet Uz Children Diseases Training and Research Hospital, University of Health Sciences, Izmir, Türkiye.
Osman DonmezDivision of Pediatric Nephrology, Faculty of Medicine, Uludag University, Bursa, Türkiye.
Mehmet Akif DurmusDepartment of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Hasan DursunDivision of Pediatric Nephrology, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Ruhan DusunselDivision of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.
Ali DuzovaDivision of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Pelin ErtanDivision of Pediatric Nephrology, Faculty of Medicine, Celal Bayar University, Manisa, Türkiye.
Asuman GedikbasiDepartment of Rare Diseases, Institute of Child Health, Istanbul University, Istanbul, Türkiye.
Nilufer GoknarDivision of Pediatric Nephrology, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Sercin GuvenDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Duygu HacihamdiogluDivision of Pediatric Nephrology, Faculty of Medicine, Bahcesehir University, Istanbul, Türkiye.
Augustina JankauskieneClinic of Pediatrics, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Mukaddes KalyoncuDivision of Pediatric Nephrology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye.
Salih KavukcuDivision of Pediatric Nephrology, Faculty of Medicine, Dokuz Eylul University, Izmir, Türkiye.
Bahriye Uzun KenanDivision of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Nuran KucukDivision of Pediatric Nephrology, Kartal Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Bahar KuralDepartment of Pediatrics, Bakirkoy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Mieczysław LitwinDivision of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Giovanni MontiniDivision of Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
William MorelloDivision of Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.
Lukasz ObryckiDivision of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Beyhan OmerDepartment of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Ebru Misirli OzdemirDepartment of Pediatrics, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Nese OzkayinDivision of Pediatric Nephrology, Faculty of Medicine, Trakya University, Edirne, Türkiye.
Dusan ParipovicDivision of Pediatric Nephrology, University Children's Hospital, Belgrade, Serbia.
Cemile PehlivanogluDivision of Pediatric Nephrology, Umraniye Training and Research Hospital, Istanbul, Türkiye.
Seha SaygiliDivision of Pediatric Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, İstanbul, Türkiye.
Franz SchaeferDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University, Heidelberg, Germany.
Susanne SchaeferDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University, Heidelberg, Germany.
Ferah SonmezDivision of Pediatric Nephrology, Faculty of Medicine, Adnan Menderes University, Aydin, Türkiye.
Yilmaz TabelDivision of Pediatric Nephrology, Faculty of Medicine, Inonu University, Malatya, Türkiye.
Nesrin TasDivision of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Mehmet TasdemirDivision of Pediatric Nephrology, School of Medicine, Koc University, Istanbul, Türkiye.
Ana TeixeiraDivision of Pediatric Nephrology, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Demet TekcanDivision of Pediatric Nephrology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Türkiye.
Rezan TopalogluDivision of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Sebahat TulparDivision of Pediatric Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Ozde Nisa TurkkanDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Berfin UysalDivision of Pediatric Nephrology, Dortcelik Children's Hospital, University of Health Sciences, Bursa, Türkiye.
Metin UysalolDivision of Pediatric Emergency, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Renata VitkevicClinic of Pediatrics, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
Sevgi YavuzDivision of Pediatric Nephrology, Kanuni Sultan Suleyman Research and Training Hospital, University of Health Sciences, Istanbul, Türkiye.
Sibel YelDivision of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.
Tarik YildirimDepartment of Pediatrics, Kanuni Sultan Suleyman Research and Training Hospital, University of Health Sciences, Istanbul, Türkiye.
Zeynep Yuruk YildirimDivision of Pediatric Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Nurdan YildizDivision of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Türkiye.
Selcuk YukselDepartment of Pediatric Rheumatology and Pediatric Nephrology, School of Medicine, Canakkale Onsekiz Mart University, Canakkale, Türkiye.
Eray YurtsevenDepartment of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Alev YilmazDivision of Pediatric Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

Indexed as

CAKUTchildrencongenital anomalies of the kidney and urinary tractheat shock proteinsHsp70UTILISE study

Identifiers

PMID40778050
PMCPMC12327326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.