Evidence map›Paper›PMID 40777821›Full record

ArticleJournal of clinical biochemistry and nutrition2025

Levosimendan alleviates myocardial ischemia-reperfusion injury by regulating mitochondrial autophagy through cGAS-STING signaling pathway.

Feng Shi, Han Bao, Fanqing Meng, Yunting Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feng ShiDepartment of Gastrointestinal and Hernia Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Lixia District, Jinan City, Shandong Province, 250000, China.
Han BaoDepartment of Anesthesiology, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University, No. 2 Jianguo Xiaojing 3rd Road, Shizhong District, Jinan City, Shandong Province, 250000, China.
Fanqing MengDepartment of Anesthesiology, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University, No. 2 Jianguo Xiaojing 3rd Road, Shizhong District, Jinan City, Shandong Province, 250000, China.
Yunting PangDepartment of Anesthesiology, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University, No. 2 Jianguo Xiaojing 3rd Road, Shizhong District, Jinan City, Shandong Province, 250000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levosimendan, a calcium sensitizer, has cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI). Mitophagy plays an important role in MIRI, and the cGAS-STING signaling pathway can participate in mitophagy in a variety of ways. The purpose of this study was to explore the new molecular mechanism by which levosimendan exerts cardioprotective effects in order to provide a new experimental basis for the clinical application of levosimendan. In this study, an isolated MIRI rat model was established, and 48 rats were randomly divided into four groups (

Indexed as

cGAS-STING signaling pathwaylevosimendanmitochondrial autophagymyocardial ischemia-reperfusion injury

Identifiers

PMID40777821
PMCPMC12326253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.