ArticleFundamental research2025
The PODNL1/AKT/β-catenin signaling axis mediates glioma progression and sensitivity to temozolomide.
Article in Fundamental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- The oncogenic role of CCDC34 in lower-grade gliomas: prognostic significance and therapeutic potential.Journal of neuro-oncology · 2025Article
- Article
- Machine learning potential predictor of idiopathic pulmonary fibrosis.Frontiers in genetics · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
Abnormal expression of small leucine-rich repeat proteins (SLRP) in tumor tissues has been reported as a critical trigger for tumorigenesis and progression. However, the molecular mechanism of PODNL1, a novel member of SLRP family, in glioma remains largely unknown. Therefore, this study aimed to investigate its correlation with clinical factors by glioma cohort and to identify the molecular mechanisms of aberrant PODNL1 gene expression in glioma. Our findings revealed that both PODNL1 mRNA and protein levels were markedly upregulated in glioma tissues, and high PODNL1 mRNA level was significantly associated with poor prognosis of glioma patients. In functional assays, PODNL1 knockdown significantly suppressed the proliferation and invasion abilities of glioma cells, while overexpression of PODNL1 had the opposite effect both
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