ArticleMolecular therapy. Nucleic acids2025
A potent GalNAc-siRNA drug, RBD1016, leads to sustained HBsAg reduction and seroconversion in mouse models of HBV infection.
Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- New Developments in the Treatment of Hepatitis B Virus Infection.Gastroenterology & hepatology · 2026Article
- siRNA approaches in HBV: From antigen reduction to seroconversion.Molecular therapy. Nucleic acids · 2025Article
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10 authors.
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Abstract
Potent small interfering RNA (siRNA) drugs that could achieve hepatitis B surface antigen (HBsAg) seroconversion and functional cure are currently lacking. The purpose of this study is to evaluate the therapeutic potential of RBD1016, a novel GalNAc-conjugated siRNA drug targeting transcripts of hepatitis B virus (HBV), in animal models. RBD1016 was designed to target X gene of HBV (HBx) and showed strong activities on HBV DNA and HBsAg for multiple HBV genotypes and nucleoside-resistant viral strains in
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