Evidence map›Paper›PMID 40777745›Full record

ArticleMolecular therapy. Nucleic acids2025

Multi-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke.

Min Wang, Chong Xu, Xiaoshan Du, Tian Zhu, Xitong Yang, Fuhui Duan, Guangyan Wang, Yongchun Zuo, Huaqiu Chen, Guangming Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min WangSchool of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.
Chong XuSchool of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.
Xiaoshan DuDepartment of Geriatrics, South District of Hefei First People's Hospital, Hefei, Anhui Province 230000, China.
Tian ZhuSchool of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.
Xitong YangCenter of Genetic Testing, The First Affiliated Hospital of Dali University, Dali, Yunnan Province 671000, China.
Fuhui DuanCenter of Genetic Testing, The First Affiliated Hospital of Dali University, Dali, Yunnan Province 671000, China.
Guangyan WangDepartment of Clinical Laboratory, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
Yongchun ZuoState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, College of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Huaqiu ChenDepartment of Laboratory, Xichang People's Hospital, Xichang, Sichuan 615000, China.
Guangming WangSchool of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke (IS) is a major cause of disability and mortality, but its genetic basis remains poorly understood. This study integrates data from three large-scale genome-wide association studies (GWASs), the GWAS Catalog, MEGASTROKE, and Open GWAS, to identify novel genetic loci linked to IS. Our meta-analysis revealed 124 new IS-associated loci, with enrichment in genes involved in cerebrovascular function, inflammation, and metabolism. Candidate genes like

Indexed as

genetic lociISischemic strokeLLM-based knowledge baseMendelian randomizationMT: Bioinformatics

Identifiers

PMID40777745
PMCPMC12328896

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.