ArticleCureus2025
Xylazine Withdrawal: A Case Report From the Intensive Care Unit to the Medical Ward.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xylazine is a centrally acting alpha-2 adrenergic agonist commonly used with fentanyl in illicit drug mixtures, yet its withdrawal profile remains poorly characterized. We report a case of a 35-year-old man with polysubstance use, significant for fentanyl with xylazine and bipolar disorder. He presented with seizure-like activity and agonal breathing, requiring intensive care unit admission. The patient's persistent hypertension, agitation, and autonomic dysregulation were inconsistent with typical opioid withdrawal or sepsis. Initial management with sedatives and multiple antihypertensives was ineffective. Agitation improved with dexmedetomidine, whereas blood pressure and autonomic control were achieved after initiation of a transdermal clonidine patch, followed by transition to oral clonidine with tapering. The adjunctive use of gabapentin, lacosamide, and quetiapine helped manage psychomotor agitation and generalized pain. The patient recovered to his baseline and was discharged to an outpatient rehabilitation program. This case highlights the importance of recognizing xylazine withdrawal as an independent toxidrome requiring targeted alpha-2 agonist therapy and supports evidence-based, multidisciplinary collaboration for symptom control and clinical stabilization.
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