ArticleCureus2025
A Delayed Adverse Reaction: Hydralazine-Induced Lupus After Years of Use.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced lupus (DIL) is a rare autoimmune condition triggered by certain medications, most commonly hydralazine and procainamide. DIL can manifest after a few weeks or even after several years of drug exposure. We present a case of a 61-year-old female with hypertension and type 2 diabetes mellitus who developed progressive polyarthritis, myalgia, and fatigue that developed over a year after three years of hydralazine use. Laboratory findings revealed anemia, leukopenia, elevated inflammatory markers, an anti-nuclear antibody (ANA) titer of 1:2560, and anti-histone antibodies of 4.9 units. A false-positive immunoglobulin M (IgM) Lyme antibody complicated the diagnostic workup. Discontinuation of hydralazine and initiation of corticosteroid and methotrexate resulted in resolution after six weeks, confirming the diagnosis of hydralazine-induced lupus.
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