Evidence map›Paper›PMID 40777613›Full record

ArticleFrontiers in urology2025

Primary large cell neuroendocrine carcinoma of the urethra: a case report.

Jianbai Chen, Xiaorong Mou, Zhiming Zhang, Zhiyong Nie, Jianxin Qiu

Abstract readCase Reports
In one paragraph

Article in Frontiers in urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jianbai ChenAir Force Medical University, Xi'an, China.
Xiaorong MouDepartment of Pathology, Tangdu Hospital, Xi'an, China.
Zhiming ZhangDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Zhiyong NieDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Jianxin QiuDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past. Case description: A 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. A biopsy subsequently confirmed the diagnosis of primary urethral LCNEC. Following radical resection, the patient exhibited abnormal lymph node enlargement in the first month and pelvic metastases in the fourth month. Ultimately, the patient succumbed to the disease 486 days after the radical resection, attributed to widespread tumor metastases and concurrent multi-organ failure. The final pathological examination confirmed the presence of a high-grade LCNEC. Conclusion: The occurrence of primary LCNEC in the urethra is exceptionally uncommon. This particular instance was notable for its aggressive progression and unfavorable prognosis. Historically, there have been no prior documented instances of primary pure LCNEC in the urethra. It is imperative to emphasize that early identification and intervention for LCNEC could potentially offer patients a more favorable survival outcome.

Indexed as

case reportlarge cell neuroendocrine carcinomaprognosisradical cystectomy (RC)urethra carcinoma

Identifiers

PMID40777613
PMCPMC12327247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.