Evidence map›Paper›PMID 40777595›Full record

ArticleGastro hep advances2025

COVID-19 Pandemic-Related Disruptions in Routine Cirrhosis Care and Associated Clinical Outcomes among San Francisco Bay Area Veterans.

Jessica B Rubin, Rebecca Loeb, Alexander Monto, Robert J Wong, Ramsey Cheung, Steven L Batki, Michael J Ostacher, Hui Shen, Katherine J Hoggatt, Derek D Satre and 1 more

Abstract read
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica B RubinDivision of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California.
Rebecca LoebDivision of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California.
Alexander MontoDivision of Gastroenterology, University of California Los Angeles, Los Angeles, California.
Robert J WongDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California.
Ramsey CheungDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California.
Steven L BatkiVA Medical Center, San Francisco Veterans Affairs Healthcare System, San Francisco, California.
Michael J OstacherVA Medical Center, Veterans Affairs Palo Alto Healthcare System, Palo Alto, California.
Hui ShenVA Medical Center, San Francisco Veterans Affairs Healthcare System, San Francisco, California.
Katherine J HoggattCenter for Data to Discovery and Delivery Innovation (3DI), San Francisco Veterans Affairs Health System, San Francisco, California.
Derek D SatreDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Mandana KhaliliDivision of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California.

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Impact of the COVID-19 pandemic on patient outcomes, telehealth care delivery, and treatment for unhealthy alcohol use in vulnerable patients with advanced liver disease across two healthcare systemsR01AA029312 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA, SATRE, DEREK D · 2021 to 2025
$3.5M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
Using real-world evidence to define safe pain management strategies in cirrhosisK23DK135901 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jessica Rubin · 2023 to 2026
$756k
NIAAA NIH HHS K24 AA022523NIAAA NIH HHS K24 AA025703NIAAA NIH HHS R01 AA029312NIDDK NIH HHS K23 DK135901NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Background and Aims: The COVID-19 pandemic disrupted health-care delivery for chronic conditions managed in specialty care and particularly among socioeconomically disadvantaged and Veteran populations. Clinical outcomes in cirrhosis are highly dependent on routine care, including clinic visits, labs, and imaging. This study examines the pandemic's impact on adherence to cirrhosis-related quality indicators and clinical outcomes among Bay Area Veterans receiving hepatology care. Methods: We conducted a retrospective cohort study of Veterans with cirrhosis seen at San Francisco and Palo Alto Veterans Affairs hepatology clinics (March 2017-March 2023). Adherence to quality indicators-hepatocellular carcinoma (HCC) screening, lab monitoring, and hepatology visits-was compared between prepandemic (2017-2020) and pandemic-postpandemic (2020-2023) periods. Multivariable logistic regression assessed the effect of time and pandemic phase on clinical outcomes, including new hepatic decompensation, new HCC, and liver-related hospitalizations or death. Results: Among 1501 Veterans with cirrhosis (median age 67 years, 97% male), adherence to quality indicators declined during the pandemic, with hepatology visits decreasing from 1.5/year to 1.0/year, and telehealth use increasing sevenfold. Overall mortality rates were higher during the pandemic (21% vs 17%) possibly related to nonliver causes, since on multivariable models, the pandemic phase was associated with lower odds of new decompensation (adjusted odds ratio (aOR) 0.87, 95% confidence interval (CI) 0.5-0.9, Conclusion: The pandemic significantly disrupted cirrhosis care among Bay Area Veterans, potentially resulting in "health debt" that may affect outcomes in coming years. Targeted interventions should re-engage patients, addressing these care gaps and improving clinical outcomes.

Indexed as

Alcohol-Associated Liver DiseaseHealth DisparityQuality of CareSARS-CoV-2Telemedicine

Identifiers

PMID40777595
PMCPMC12329098

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.