Evidence map›Paper›PMID 40777554›Full record

ArticleLaryngoscope investigative otolaryngology2025

Disparities in the Receipt of Immunotherapy for Patients With Head and Neck Mucosal Melanoma.

Areeb Shah, Peter Q Luong, Joshua B Smith, Matthew Simpson, Sean T Massa

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Areeb ShahSaint Louis University School of Medicine St. Louis MO USA.ORCID https://orcid.org/0009-0008-3555-8641
Peter Q LuongDepartment of Otolaryngology-Head and Neck Surgery Saint Louis University School of Medicine St. Louis MO USA.
Joshua B SmithDepartment of Otolaryngology-Head and Neck Surgery Saint Louis University School of Medicine St. Louis MO USA.
Matthew SimpsonDepartment of Otolaryngology-Head and Neck Surgery Saint Louis University School of Medicine St. Louis MO USA.ORCID https://orcid.org/0000-0001-9476-1326
Sean T MassaDepartment of Otolaryngology-Head and Neck Surgery Saint Louis University School of Medicine St. Louis MO USA.ORCID https://orcid.org/0000-0003-2015-9855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the relationship between socioeconomic status (SES) and the use of immunotherapy (IT) in patients with head and neck mucosal melanoma (HNMM); and to assess trends in 3-year overall survival (OS) associated with IT. Methods: This retrospective study used National Cancer Database (NCDB) data from 2004 to 2021. SES was assessed using a composite measure incorporating race, ethnicity, insurance status, and rural residence. Trends in IT use and OS were evaluated using Joinpoint analysis. Multivariable logistic regression and Cox proportional hazards models assessed associations between SES, IT receipt, and OS. Sensitivity analyses were performed by SES components and time period. Results: Among 3163 patients, 22.7% received IT. Use of IT increased over time (2013-2021 AAPC: 21.9%, 95% CI: 19.6-26.9) without significant differences between SES groups. SES was not associated with IT receipt (aOR: 1.15; 95% CI: 0.84-1.55) or OS (aHR: 0.94; 95% CI: 0.78-1.13). IT was not associated with improved OS (aHR: 1.05; 95% CI: 0.87-1.26). Conclusion: Despite increasing IT use, no disparities in access or survival by SES were observed. While survival improved modestly over time, IT was not independently associated with this trend. These findings highlight equitable IT use in HNMM and underscore the need for future prospective studies to clarify its survival impact.

Indexed as

head and neck cancerimmunotherapymucosal melanoma

Identifiers

PMID40777554
PMCPMC12329909

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.