ArticlebioRxiv : the preprint server for biology2025
Intrinsic noise reveals the stability of a neuronal network.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
The stability of rhythmic activity in neural networks is an important aspect in the study of central pattern generators (CPGs). Different from other physiological rhythms, the activity of CPGs has not been fully characterized in terms of its stability, especially using quantitative methods. We propose a method that takes advantage of the natural noise present in CPGs to quantify the stability of the rhythmic activity. Furthermore, we used the stationary bootstrap method to define confidence intervals of the results. We applied this method to study the influence of a synaptic modification on the pyloric CPG circuit, using artificial synapses implemented in dynamic clamp software. We show that even after removing one of its strongest synapses, the CPG stability remains unaltered. This analysis suggests that CPGs are designed to be strongly stable regardless of the parameter perturbations they undergo.
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