Evidence map›Paper›PMID 40777492›Full record

ArticlebioRxiv : the preprint server for biology2025

FLEXTAG: A Small and Self-renewable Protein Labeling System for Anti-fading Multicolor Super-resolution Imaging.

Han Zhang, Yuan Yao, Xuye Wang, Yuan Tao, Haopeng Yang, Yinqi Wang, Mengde Liu, Marina Feric, Ruobo Zhou

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Han ZhangDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0009-0007-0111-5351
Yuan YaoDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Xuye WangDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Yuan TaoDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Haopeng YangDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0009-0009-1690-4315
Yinqi WangDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Mengde LiuDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Marina FericDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-7531-9305
Ruobo ZhouDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-8628-0282

Funding

Deciphering the functional role of actin-spectrin-based membrane skeleton in subcellular compartmentalization of signaling proteins and cell signal transductionR35GM142973 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI ZHOU, RUOBO · 2021 to 2025
$2.2M
Flow Of Gene Expression Across Mitochondrial CondensatesR35GM154931 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Marina Feric · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM142973NIGMS NIH HHS R35 GM154931
6 · The paper itself

Abstract

Super-resolution fluorescence imaging enables visualization of subcellular structures and molecular interactions at the nanoscale, but its broader application has been hindered by long-standing limitations in current protein tagging systems, including rapid photobleaching, tag-induced artifacts, poor post-fixation labeling efficiency, and restricted multiplexing capability. Here, we present

Identifiers

PMID40777492
PMCPMC12330666

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.