Evidence map›Paper›PMID 40777479›Full record

ArticlebioRxiv : the preprint server for biology2025

Developmental time course of social touch, parvalbumin interneurons, perineuronal nets and Mef2c expression reveals a sensitive period of somatosensory cortex development in prairie voles.

Noah E P Milman, Nathan M McGuire, Jasmine M Loeung, Lezio S Bueno-Junior, Carolyn E Tinsley, Hannah Bronstein, Felice D Kelly, Peyton T Wickham, Anjesh Ghimire, Zachary Johnson and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Noah E P MilmanORCID 0000-0003-0688-0427
Nathan M McGuireORCID 0009-0007-9209-6255
Jasmine M LoeungORCID 0009-0009-0190-6625
Lezio S Bueno-JuniorORCID 0000-0002-8530-8105
Carolyn E TinsleyORCID 0000-0002-7673-0275
Hannah BronsteinORCID 0009-0000-3557-1071
Felice D KellyORCID 0000-0002-9596-2944
Peyton T WickhamORCID 0000-0003-4042-787X
Anjesh GhimireORCID 0000-0002-5483-9456
Zachary JohnsonORCID 0000-0002-0101-6309
Harry PantazopoulosORCID 0000-0002-8905-8377
Brendon O WatsonORCID 0000-0002-9940-4579
Barbara A SorgORCID 0000-0002-4913-4910
Miranda M LimORCID 0000-0003-3876-3196

Funding

Neuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3M
Cocaine, Parvalbumin, and Perineuronal NetsR01DA055645 · NIDA · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI SUE A AICHER, Travis Eugene Brown · 2023 to 2026
$2.9M
Role of early-life sleep and sensory environment in shaping the development of affiliative behavior and PV-interneurons in the somatosensory cortex of the highly social prairie vole.F31MH136684 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Noah Emery Pollak Milman · 2024 to 2026
$99k
NIA NIH HHS T32 AG055378NIDA NIH HHS R01 DA055645NIMH NIH HHS F31 MH136684
6 · The paper itself

Abstract

Social touch facilitates our attachment to others, especially early in life, which may be linked to the maturation of parvalbumin interneurons (PVI) in the somatosensory cortex (S1). These neurons respond to social touch, mature in a sensory experience-dependent manner, and influence both somatosensory processing and social behavior in models of Autism Spectrum Disorder. Prairie voles (

Identifiers

PMID40777479
PMCPMC12330645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.