Evidence map›Paper›PMID 40777478›Full record

ArticlebioRxiv : the preprint server for biology2025

Arrayed single-gene perturbations identify drivers of human anterior neural tube closure.

Roya E Huang, Giridhar M Anand, Heitor C Megale, Jason Chen, Chudi Abraham-Igwe, Sharad Ramanathan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Roya E HuangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-7267-4758
Giridhar M AnandDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Heitor C MegaleDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Jason ChenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Chudi Abraham-IgweDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Sharad RamanathanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-9445-1248

Funding

Measuring and modeling the dynamics ofpatterning in human stem cellsR01GM131105 · NIGMS · HARVARD UNIVERSITY · PI Sharad Ramanathan · 2019 to 2026
$2.9M
Platform to accurately recapitulate and perturb cortical development and morphogenesis in vitroR01MH136014 · NIMH · HARVARD UNIVERSITY · PI Sharad Ramanathan · 2025 to 2026
$1.3M
NIGMS NIH HHS R01 GM131105NIMH NIH HHS R01 MH136014
6 · The paper itself

Abstract

Genetic studies of human embryonic morphogenesis are constrained by ethical and practical challenges, restricting insights into developmental mechanisms and disorders. Human pluripotent stem cell (hPSC)-derived organoids provide a powerful alternative for the study of embryonic morphogenesis. However, screening for genetic drivers of morphogenesis

Indexed as

bioengineeringhigh-throughputhumanmorphogenesisneural tubeorganoidsreproducibleStem cell

Identifiers

PMID40777478
PMCPMC12330715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.