Evidence map›Paper›PMID 40777471›Full record

ArticlebioRxiv : the preprint server for biology2025

Segmental copy number amplifications are stable in the absence of selection.

Titir De, Nadav Ben Nun, Pieter Spealman, Ina Suresh, Grace Avecilla, Farah Abdul-Rahman, Yoav Ram, David Gresham

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Titir DeCenter for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID 0000-0002-4006-4880
Nadav Ben NunSchool of Zoology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0009-0003-3228-7720
Pieter SpealmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-7105-284X
Ina SureshCenter for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID 0009-0007-7712-0288
Grace AvecillaBaruch College, City University of New York, New York, NY, USA.ORCID 0000-0003-1525-0873
Farah Abdul-RahmanMicrobial Sciences Institute, Yale University, New Haven, CT, USA.ORCID 0000-0001-6854-570X
Yoav RamSchool of Zoology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-9653-4458
David GreshamCenter for Genomics and Systems Biology, New York University, New York, NY, USA.ORCID 0000-0002-4028-0364

Funding

Regulated and evolutionary responses to nutritional stressR35GM153419 · NIGMS · NEW YORK UNIVERSITY · PI David Gresham · 2024 to 2026
$1.8M
NIGMS NIH HHS R35 GM153419
6 · The paper itself

Abstract

Copy number variants (CNVs) are duplications and deletions of DNA sequences that contribute to genetic variation between individuals and underlie rapid adaptive evolution. Increases in gene copy number can confer a strong selective advantage in some circumstances, but CNVs can also incur fitness costs. Prior research has shown that experimental evolution of

Identifiers

PMID40777471
PMCPMC12330549

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.