Evidence map›Paper›PMID 40777467›Full record

ArticlebioRxiv : the preprint server for biology2025

ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune Evasion.

Benjamin Ziman, Talia A Wenger, Chehyun Nam, Qian Yang, Daniel Arnaudov, Megha Sheth, Zhixuan Jing, Yuhao Pan, Joe Vargas, Yong Teng and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Benjamin ZimanCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0951-3534
Talia A WengerCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Chehyun NamCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Qian YangDepartment of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel ArnaudovCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Megha ShethCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Zhixuan JingCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Yuhao PanCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Joe VargasBiocare Medical, Pacheco, CA, USA.
Yong TengDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Uttam K SinhaDepartment of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Young Min ParkDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
De-Chen LinCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Master regulator transcription factors promote esophageal neoplastic evolutionR37CA237022 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIN, DE-CHEN · 2020 to 2025
$2.7M
Modeling Pathways of Early Growth Dysregulation at the GEJR01DK135562 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI De-Chen Lin, Stephen J Meltzer · 2024 to 2026
$2.1M
Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancerR01DE033648 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI De-Chen Lin · 2024 to 2026
$1.5M
NCI NIH HHS P30 CA014089NCI NIH HHS R37 CA237022NIDCR NIH HHS R01 DE033648NIDDK NIH HHS R01 DK135562
6 · The paper itself

Abstract

Transcriptional Intratumoral heterogeneity (ITH) is a hallmark of aggressive cancers, yet how transcriptional ITH programs drive tumor metastasis and immune evasion in upper aerodigestive squamous cell carcinoma (UASCC) remains unclear. Through single-cell RNA sequencing analysis of UASCC cells and patient tumors, we uncovered a hybrid epithelial mesenchymal transition (hEMT) ITH program linked to metastatic dissemination. The transcription factor ETS1 was identified as a master regulator of the hEMT program, directly activating pro-metastatic genes and promoting distant spread in vivo. Unexpectedly, ETS1 also orchestrated an immune-cold tumor microenvironment by transcriptionally activating both

Identifiers

PMID40777467
PMCPMC12330640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.