Evidence map›Paper›PMID 40777446›Full record

ArticlebioRxiv : the preprint server for biology2025

A framework to infer

Haeun Moon, Laura Sloofman, Marina Natividad Avila, Lambertus Klei, Bernie Devlin, Joseph D Buxbaum, Kathryn Roeder

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Haeun MoonDepartment of Statistics, Seoul National University, Seoul, South Korea.
Laura SloofmanSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Marina Natividad AvilaSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lambertus KleiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bernie DevlinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joseph D BuxbaumSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8898-8313
Kathryn RoederDepartment of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

Funding

Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputationR01MH123184 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI KATHRYN M ROEDER · 2020 to 2026
$3.8M
Genomics of Autism in Latinx AncestriesR01MH128813 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph D. Buxbaum · 2022 to 2026
$3.7M
1/4 - The Autism Sequencing Consortium: Autism Gene Discovery in >50,000 ExomesU01MH111661 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUXBAUM, JOSEPH D. · 2017 to 2021
$2.6M
1/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorderR01MH129724 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph D. Buxbaum · 2022 to 2026
$2.0M
3/4 - The Autism Sequencing Consortium: Autism Gene Discovery in >50,000 ExomesU01MH111658 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE · 2017 to 2021
$2.0M
3/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorderR01MH129725 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI KATHRYN M ROEDER · 2022 to 2026
$1.9M
NIMH NIH HHS R01 MH123184NIMH NIH HHS R01 MH128813NIMH NIH HHS R01 MH129724NIMH NIH HHS R01 MH129725NIMH NIH HHS U01 MH111658NIMH NIH HHS U01 MH111661
6 · The paper itself

Abstract

Motivation: Gene-damaging mutations are highly informative for studies seeking to discover genes underlying developmental disorders. Traditionally, these Results: We use data from autism spectrum disorder to illustrate and evaluate methods. Separating Availability and Implementation: The implementation code and publicly available data are provided at: https://github.com/HaeunM/TADA-RD.

Indexed as

autism spectrum disorderclassificationcongenital heart diseasede novo mutationgenetic association

Identifiers

PMID40777446
PMCPMC12330658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.