Evidence map›Paper›PMID 40777440›Full record

ArticlebioRxiv : the preprint server for biology2025

PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development.

Qootsvenma Denipah-Cook, Bryanna V Saxton, Kristin B Artinger, Lomeli C Shull

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Qootsvenma Denipah-CookDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.
Bryanna V SaxtonDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.
Kristin B ArtingerDepartment of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA.
Lomeli C ShullDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.

Funding

Function of chromatin modifiers in cranial neural crest developmentR01DE024034 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI ARTINGER, KRISTIN, NISWANDER, LEE A. · 2015 to 2019
$3.2M
Functions of PRDM Histone Methyltransferases during Cartilage Development in the Craniofacial SkeletonR00DE031349 · NIDCR · UNIVERSITY OF NEW MEXICO · PI Lomeli Carpio Shull · 2025 to 2026
$455k
Functions of PRDM Histone Methyltransferases during Cartilage Development in the Craniofacial SkeletonK99DE031349 · NIDCR · UNIVERSITY OF NEW MEXICO · PI SHULL, LOMELI CARPIO · 2022 to 2023
$200k
NIDCR NIH HHS K99 DE031349NIDCR NIH HHS R00 DE031349NIDCR NIH HHS R01 DE024034
6 · The paper itself

Abstract

Mandibular bone development utilizes both endochondral ossification, forming from the cartilaginous anlage Meckel's cartilage derived from neural crest cells (NCC) and intramembranous ossification with direct differentiation of NCCs toward osteoblasts. Wnt/β-catenin signaling drives osteogenic vs chondrogenic differentiation and must be tightly controlled during the differentiation of osteochondroprogenitors. Chromatin remodelers add hierarchal regulation to the activation and repression of crucially timed gene regulatory networks and signaling cascades. In this study, we investigated the function of two chromatin remodelers-histone methyltransferases, PRDM3 and PRDM16 during murine craniofacial development. Conditionally ablating both

Indexed as

craniofacialMeckel’s cartilageMecom/Evi1Prdm16Prdm3Wnt/β-catenin

Identifiers

PMID40777440
PMCPMC12330695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.