Evidence map›Paper›PMID 40777421›Full record

ArticlebioRxiv : the preprint server for biology2025

Wnt5a gain- and loss-of-function present distinctly in craniofacial bone.

Claire J Houchen, Portia Hahn Leat, Cassandra Delich, Jocelyn Vang, Sara Haggard, Joseph L Roberts, Hicham Drissi, Erin E Bumann

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Claire J HouchenUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.ORCID 0000-0002-2003-4625
Portia Hahn LeatUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.
Cassandra DelichUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.ORCID 0009-0009-9109-2839
Jocelyn VangUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.
Sara HaggardUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.
Joseph L RobertsEmory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6839-1173
Hicham DrissiEmory University School of Medicine, Atlanta, GA.ORCID 0000-0002-3322-281X
Erin E BumannUniversity of Missouri-Kansas City School of Dentistry, Kansas City, MO.ORCID 0000-0002-8698-7808

Funding

Wnt5a/Ror2 Signaling in Jaw Bone DevelopmentR03DE031388 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI BUMANN, ERIN EALBA · 2021 to 2023
$390k
Bone anabolic effects of osteoclast-produced phospho-Wnt5aR56AR080718 · NIAMS · EMORY UNIVERSITY · PI DRISSI, MOULAY HICHAM · 2023 to 2023
$313k
NIAMS NIH HHS R56 AR080718NIDCR NIH HHS R03 DE031388
6 · The paper itself

Abstract

Introduction: Robinow syndrome has characteristic craniofacial and dental features and can be caused by gain- or loss-of-function variants in Wnt family member 5A ( Methods: To investigate the role of Results: Conditional Conclusions: Craniofacial and dental phenotype differed between mice with conditional GOF and LOF of

Identifiers

PMID40777421
PMCPMC12330612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.