Evidence map›Paper›PMID 40777403›Full record

ArticlebioRxiv : the preprint server for biology2025

Adrenergic signaling coordinates distant and local responses to amputation in axolotl.

Duygu Payzin-Dogru, Tim Froitzheim, Steven J Blair, Siddhartha G Jena, Hani Singer, Julia C Paoli, Ryan T Kim, Emil Kriukov, Sarah E Wilson, Renzhi Hou and 28 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Duygu Payzin-DogruDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0002-3717-0244
Tim FroitzheimDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Steven J BlairDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Siddhartha G JenaDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Hani SingerDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Julia C PaoliDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Ryan T KimDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Emil KriukovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA, 02114.
Sarah E WilsonDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Renzhi HouDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA, 92617.
Aaron M SavageDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0002-2636-6145
Victor CatDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Louis V CammarataDepartment of Statistics, Harvard University, Cambridge, MA, USA, 02138.
S Y Celeste WuDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Vivien BotheMuseum für Naturkunde Berlin, Berlin, Germany.ORCID 0000-0002-3402-1809
Burcu ErdoganDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Shifa HossainDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Noah LopezDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0001-7005-298X
Julia LosnerDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0001-5875-6351
Juan Velazquez MatosDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Sangwon MinDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0001-9744-5847
Sebastian BöhmDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Anthony E StrikerDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Kelly E DoolingDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0009-0002-5029-7220
Adam H FreedmanInformatics Group, Harvard University, 38 Oxford St., Cambridge, MA, USA, 02138.ORCID 0000-0003-4714-3925
Bobby GrovesDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Benjamin TajerDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Glory KaluDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Eric WynnDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Alan Y L WongDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Nadia FröbischSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA, 92617.
Petr BaranovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA, 02114.ORCID 0000-0002-5526-7058
Maksim V PlikusDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA, 92617.
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.
Brian J HaasThe Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02138.ORCID 0000-0002-6609-4973
Isaac M ChiuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA, 02115.ORCID 0000-0002-0723-4841
Timothy B SacktonInformatics Group, Harvard University, 38 Oxford St., Cambridge, MA, USA, 02138.ORCID 0000-0003-1673-9216
Jessica L WhitedDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard University, 7 Divinity Ave., Cambridge, MA, USA, 02138.ORCID 0000-0002-3709-6515

Funding

Leveraging Single-Cell Analysis to Elucidate Mechanisms of Vertebrate LimbRegenerationDP2HD087953 · NICHD · HARVARD UNIVERSITY · PI WHITED, JESSICA L. · 2015 to 2020
$3.2M
Roles of body-wide injury responses in axolotl limb regenerationR01HD115272 · NICHD · HARVARD UNIVERSITY · PI JESSICA L. WHITED · 2024 to 2026
$2.5M
IDENTIFYING ROADBLOCKS TO LIMB REGENERATIONR01HD095494 · NICHD · HARVARD UNIVERSITY · PI WHITED, JESSICA L. · 2019 to 2023
$1.9M
Interdisciplinary Training Program in Skin BiologyT32AR080622 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen, Anand K Ganesan · 2022 to 2026
$909k
NIAMS NIH HHS T32 AR080622NICHD NIH HHS DP2 HD087953NICHD NIH HHS R01 HD095494NICHD NIH HHS R01 HD115272
6 · The paper itself

Abstract

Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we discovered a role for the sympathetic nervous system in stimulating a body-wide stem cell activation response to amputation that drives enhanced limb regeneration in axolotls. This response is mediated by adrenergic signaling, which coordinates distant cellular activation responses via the α

Indexed as

amputationlimbmTORnoradrenalinenorepinephrineperipheral nervous systemprogenitor cellsregenerationstem cellssystemic responses

Identifiers

PMID40777403
PMCPMC12330692

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.