Evidence map›Paper›PMID 40777385›Full record

ArticlebioRxiv : the preprint server for biology2025

The CPEB ortholog Orb2 regulates brain size through the TRIM-NHL RNA-binding protein, Brain tumor.

Taylor Hailstock, Joseph Buehler, Beverly V Robinson, Timothy C H Low, Yuqing Hua, Temitope H Adebambo, Jack Govaerts, Todd A Schoborg, Howard D Lipshitz, Dorothy A Lerit

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor HailstockDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Joseph BuehlerDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Beverly V RobinsonDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Timothy C H LowDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario Canada M5G 1M1.
Yuqing HuaEmory College of Arts and Science, Emory University, Atlanta, GA 30322.
Temitope H AdebamboDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-1597-0507
Jack GovaertsDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071.
Todd A SchoborgDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071.ORCID 0000-0003-0017-0942
Howard D LipshitzDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario Canada M5G 1M1.ORCID 0000-0002-7372-4419
Dorothy A LeritDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-3362-8078

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM008367 · NIGMS · EMORY UNIVERSITY · PI BOISE, LAWRENCE H., CORBETT, ANITA H. · 1990 to 2019
$5.6M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
Post-transcriptional mechanisms of centrosome regulationR01GM138544 · NIGMS · EMORY UNIVERSITY · PI LERIT, DOROTHY A · 2020 to 2024
$1.8M
Defining multifunctional roles for proteins in development and diseaseR35GM155195 · NIGMS · UNIVERSITY OF WYOMING · PI Todd Schoborg · 2024 to 2026
$1.1M
Mechanisms of RNA localization and centrosome regulationR35GM158404 · NIGMS · EMORY UNIVERSITY · PI Dorothy A Lerit · 2025 to 2026
$843k
Elucidating the mechanisms of Orb2 mediated neural stem cell asymmetry and divisionF31NS134380 · NINDS · EMORY UNIVERSITY · PI BUEHLER, JOSEPH · 2023 to 2025
$146k
NCI NIH HHS P30 CA138292NIGMS NIH HHS R01 GM138544NIGMS NIH HHS R35 GM155195NIGMS NIH HHS R35 GM158404NIGMS NIH HHS T32 GM008367NIGMS NIH HHS T32 GM008490NIGMS NIH HHS T32 GM135060NIH HHS P40 OD010949NIH HHS P40 OD018537NINDS NIH HHS F31 NS134380
6 · The paper itself

Abstract

Neurodevelopment requires precise translational control, the disruption of which is implicated in various neurological disorders, including developmental delays, intellectual disability, and microcephaly. We report a novel role for the

Indexed as

brain growthmicrocephalymodels of human diseaseneurodevelopmentorgan size

Identifiers

PMID40777385
PMCPMC12330577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.