Evidence map›Paper›PMID 40777370›Full record

ArticlebioRxiv : the preprint server for biology2025

RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.

Elizabeth A Mendes, Aanandi Munshi, Archana Singh, Maisie D Evans, Hsien-Chao Chou, Yong Yean Kim, Young Song, Ara Jo, Daniel Lee, Jaida Ciampi and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elizabeth A MendesDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-1296-7879
Aanandi MunshiDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-6899-4038
Archana SinghNorwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.ORCID 0000-0002-5027-4582
Maisie D EvansNorwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.ORCID 0000-0002-9064-8120
Hsien-Chao ChouOncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-4870-9663
Yong Yean KimOncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-5417-9232
Young SongOncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Ara JoDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-0673-2053
Daniel LeeDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0009-0008-0478-6473
Jaida CiampiDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0009-0000-8146-5739
Audrey ChambersDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0009-0006-4327-6201
Samantha WeitzelDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0009-0001-0372-8406
Michael DeelDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-8634-8109
Rex C BentleyDepartment of Pathology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-4947-9150
Javed KhanOncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Darrell GreenNorwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.ORCID 0000-0002-0217-3322
Corinne M LinardicDivision of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-3257-2885

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
Screening for Cys-Reactive Ligands to Target PAX3-FOXO1U54CA231630 · NCI · DUKE UNIVERSITY · PI LINARDIC, CORINNE MARY · 2019 to 2023
$6.5M
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology CenterUM1CA239755 · NCI · DUKE UNIVERSITY · PI Shannon Jones McCall · 2019 to 2026
$5.4M
Cell and Molecular Biology Training ProgramT32GM142605 · NIGMS · DUKE UNIVERSITY · PI MICHAEL S BOYCE, Stefano Di Talia · 2021 to 2026
$3.7M
NCI NIH HHS P30 CA014236NCI NIH HHS U54 CA231630NCI NIH HHS UM1 CA239755NIGMS NIH HHS T32 GM142605
6 · The paper itself

Abstract

Fusion-positive rhabdomyosarcoma is an aggressive pediatric cancer of skeletal muscle lineage, with a 5-year overall survival of <30% for high-risk disease, and <8% when metastatic. The

Indexed as

CADD522PAX3::FOXO1RhabdomyosarcomaRMSRUNX2

Identifiers

PMID40777370
PMCPMC12330556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.