Evidence map›Paper›PMID 40777364›Full record

ArticlebioRxiv : the preprint server for biology2025

SHAPE-based chemical probes for studying preQ

José A Reyes Franceschi, Emilio L Cárdenas, Brandon J C Klein, Chase A Weidmann, Amanda L Garner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

José A Reyes FranceschiProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Emilio L CárdenasDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Brandon J C KleinDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Chase A WeidmannDepartment of Biological Chemistry, Center for RNA Biomedicine, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-2941-0500
Amanda L GarnerProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-0870-3347

Funding

Chemical Biology Approaches for Investigating RNA-Protein InteractionsR35GM153185 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Amanda Garner · 2024 to 2026
$1.6M
Delineating the Biology of Translational Repressor 4E-BP1R01GM132342 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARNER, AMANDA · 2020 to 2023
$1.4M
Developing RNP-MaP into a broad-spectrum toolset for discovery, definition, and drug targeting of RNA-protein complexes in live cellsR01GM155542 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Chase A Weidmann · 2024 to 2026
$940k
NIGMS NIH HHS R01 GM132342NIGMS NIH HHS R01 GM155542NIGMS NIH HHS R35 GM153185
6 · The paper itself

Abstract

Interrogating RNA-small molecule interactions inside cells is critical for advancing RNA-targeted drug discovery. In particular, chemical probing technologies that both identify small molecule-bound RNAs and define their binding sites in the complex cellular environment will be key for establishing the on-target activity necessary for successful hit-to-lead campaigns. Using the small molecule metabolite preQ

Indexed as

chemical probespreQ1RNASHAPESHAPE-MaPsmall moleculestarget engagement

Identifiers

PMID40777364
PMCPMC12330648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.