Evidence map›Paper›PMID 40777362›Full record

ArticlebioRxiv : the preprint server for biology2025

Big1 is a cell cycle regulator linking cell size to basal body number.

Alexander J Stemm-Wolf, Adam W J Soh, Lisa E Mitchell, Huangqingbo Sun, Erik Collet, Gayatri L Dholakia, Vikram Raju, Jay R Hesselberth, J Matthew Taliaferro, Robert F Murphy and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexander J Stemm-WolfDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-3325-2047
Adam W J SohDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-3931-1765
Lisa E MitchellDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-2695-7594
Huangqingbo SunRay and Stephanie Lane Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0002-8206-511X
Erik ColletDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0009-0007-0307-5226
Gayatri L DholakiaDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-5575-5799
Vikram RajuDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.
Jay R HesselberthDepartment of Biochemistry and Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0002-6299-179X
J Matthew TaliaferroDepartment of Biochemistry and Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0001-7580-1433
Robert F MurphyRay and Stephanie Lane Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0003-0358-901X
Lydia R HeasleyDepartment of Biochemistry and Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045.ORCID 0000-0003-1915-6593

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Nanopore analysis of transfer RNA forms and functionsR35GM119550 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jay R Hesselberth · 2016 to 2026
$4.5M
Predoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7M
Centriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5M
Properties and mechanisms of punctuated genome instabilityR00GM134193 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI HEASLEY, LYDIA RENE · 2022 to 2024
$747k
NCI NIH HHS P30 CA046934NIGMS NIH HHS R00 GM134193NIGMS NIH HHS R35 GM119550NIGMS NIH HHS R35 GM140813NIGMS NIH HHS T32 GM136444
6 · The paper itself

Abstract

Cell size control in dividing cells coordinates cell growth with cell division. In the ciliated protozoan,

Indexed as

basal bodycell cyclecell sizeTetrahymena thermophila

Identifiers

PMID40777362
PMCPMC12330541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.