ArticlebioRxiv : the preprint server for biology2025
Resistance, heteroresistance and fitness costs drive colistin treatment failure during
Juan Hernandez-Bird, Bixi He, Leah M VanOtterloo, Elizabeth B Billings, Wenwen Huo, Gabriella I C Teodoro, Haley Echlin, Jason M Rosch, M Stephen Trent, Ralph R Isberg
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Juan Hernandez-BirdDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0002-6106-2438 Bixi HeDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0002-2796-7620 Leah M VanOtterlooDepartment of Microbiology, College of Arts and Sciences, University of Georgia, GA, USA.ORCID 0009-0008-6302-0902 Elizabeth B BillingsDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0002-4320-3276 Wenwen HuoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0001-5112-1951 Gabriella I C TeodoroDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0001-9669-5940 M Stephen TrentDepartment of Microbiology, College of Arts and Sciences, University of Georgia, GA, USA.ORCID 0000-0001-6134-1800 Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, MA, USA.ORCID 0000-0002-8330-3554 Funding
Innovative technologies to transform antibiotic discovery. Project 4 Infection site-specific amplification of antimicrobial conjugatesU19AI142780 · NIAID · BROAD INSTITUTE, INC. · PI HUNG, DEBORAH T · 2019 to 2023
$33.9MPredicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2MDrug resistance enablers and their role in antibiotic treatment failureU19AI158076 · NIAID · BROAD INSTITUTE, INC. · PI COOPER, VAUGHN, ISBERG, RALPH R. · 2022 to 2025
$10.0MHigh-Throughput DNA SequencerS10OD032203 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$804kIdentification of the Achilles’ heel in Acinetobacter fluoroquinolone-resistant mutantsR21AI128328 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2018
$454kNIAID NIH HHS R21 AI128328NIAID NIH HHS U01 AI124302NIAID NIH HHS U19 AI142780NIAID NIH HHS U19 AI158076NIH HHS S10 OD032203
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Identifiers
PMID40777351
PMCPMC12330716
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