Evidence map›Paper›PMID 40777325›Full record

ArticlebioRxiv : the preprint server for biology2025

An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial protein import.

Max J Bachochin, Kelly L McGuire, Brian D Cook, Qiaozhen Ye, Steve Silletti, Kevin D Corbett, Elizabeth A Komives, Mark A Herzik

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Max J BachochinDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0002-0989-1538
Kelly L McGuireDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0009-0005-7520-3675
Brian D CookDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0002-5777-3464
Qiaozhen YeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0002-3942-4121
Steve SillettiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0001-5854-2388
Elizabeth A KomivesDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0001-5264-3866
Mark A HerzikDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.ORCID 0000-0001-6653-6682

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis (Equipment Supplement)R35GM138206 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HERZIK, MARK ANTHONY · 2020 to 2024
$2.1M
Acquisition of an Orbitrap Elite with ETDS10OD021724 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 2016 to 2016
$600k
Synapt G2-S System with HXMS AutomationS10OD016234 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 2013 to 2013
$600k
NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM138206NIGMS NIH HHS R35 GM144121NIGMS NIH HHS T32 GM008326NIH HHS S10 OD016234NIH HHS S10 OD021724
6 · The paper itself

Abstract

Tom70 mediates mitochondrial protein import by coordinating the transfer of cytosolic preproteins from Hsp70/Hsp90 to the translocase of the outer membrane (TOM) complex. In humans, the cytosolic domain of Tom70 (

Identifiers

PMID40777325
PMCPMC12330529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.