ArticlebioRxiv : the preprint server for biology2025
Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
30 authors.
Yosuke OchiaiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Hiroki KobayashiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Masaki SunagawaDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Taisuke BabaDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Ermanno MalagolaDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Feijing WuDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Takayuki TanakaDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Masahiro HataDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Junya AraiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Zhengyu JiangDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Ruth A WhiteLaura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, 10016, USA.
Xiaofei ZhiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Jin QianDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Quin T WaterburyDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Ruhong TuDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Biyun ZhengDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Yi ZengDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Hualong ZhengDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Puran ZhangDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Shuang LiDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Leah B ZamechekDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Jonathan S LaBellaDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Takahiro SugieDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Tadashi IidaDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Atsushi EnomotoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.
Holger K EltzschigDepartment of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Carmine F PalermoDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Iok In Christine ChioDepartment of Genetics & Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kenneth P OliveDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Timothy C WangDivision of Digestive and Liver Diseases and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0001-5730-3019
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2MThe Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2MTHE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATIONR01DK048077 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, TIMOTHY CRAGIN · 1995 to 2020
$5.9MFunctional Role of HIF-PHDs in ARDSR01HL169519 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Xiaoyi Yuan · 2023 to 2026
$2.7MCircadian Rhythm as a Therapeutic Target for Perioperative CardioprotectionR01HL165748 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, JOCHEN DANIEL MUEHLSCHLEGEL · 2023 to 2026
$2.6MmicroRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2MTargeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8MTargeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung DiseaseR35HL177402 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig · 2025 to 2026
$1.1MA multi-wavelength lighsheet microscope for volumetric imagingS10OD023587 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PETERKA, DARCY S · 2017 to 2017
$236kNCI NIH HHS P30 CA013696NCI NIH HHS R35 CA210088NHLBI NIH HHS R01 HL154720NHLBI NIH HHS R01 HL165748NHLBI NIH HHS R01 HL169519NHLBI NIH HHS R35 HL177402NIDDK NIH HHS P30 DK132710NIDDK NIH HHS R01 DK048077NIDDK NIH HHS R01 DK122796NIH HHS S10 OD023587
Abstract
Nerves have been shown to regulate cancer progression. However, a clear demonstration of a role for axon guidance molecules in pancreatic tumorigenesis, innervation, and metastasis has been lacking. Using murine
Indexed as
epithelial-mesenchymal transitionNeogenin-1Netrin-1pancreatic cancersympathetic nerve
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.