Evidence map›Paper›PMID 40777296›Full record

ArticlebioRxiv : the preprint server for biology2025

Astrocytes connect specific brain regions through plastic gap junctional networks.

Melissa L Cooper, Maria Clara Selles, Michael Cammer, Holly K Gildea, Joseph Sall, Katelyn E Chiurri, Aiman S Saab, Shane A Liddelow, Moses V Chao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Melissa L CooperInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0003-4337-8356
Maria Clara SellesInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-0008-6081
Michael CammerMicroscopy Laboratory, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0003-4930-1739
Holly K GildeaInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-9549-890X
Joseph SallMicroscopy Laboratory, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0001-8585-175X
Katelyn E ChiurriInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0009-0006-8275-2223
Aiman S SaabInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3886-8369
Shane A LiddelowInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-0840-1437
Moses V ChaoInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY USA.ORCID 0000-0002-6969-3744

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Christopher Mar · 2018 to 2026
$36.4M
Training Systems and Integrative NeuroscienceT32MH019524 · NIMH · NEW YORK UNIVERSITY · PI KIORPES, LYNNE · 1992 to 2025
$5.2M
Neurotoxicity of Reactive Astrocyte-secreted Lipids in Neurodegenerative DiseaseR01EY033353 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Shane Liddelow · 2022 to 2026
$2.5M
The role of glia in monitoring neuronal proteostasis in agingK00AG068343 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GILDEA, HOLLY KATHERINE · 2022 to 2025
$338k
Astrocyte Network Facilitation of NeuroplasticityK99NS139313 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Melissa L Cooper · 2025 to 2026
$282k
NCI NIH HHS P30 CA016087NEI NIH HHS R01 EY033353NIA NIH HHS K00 AG068343NIMH NIH HHS T32 MH019524NINDS NIH HHS K99 NS139313NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Traditionally, neuronal axons have been considered the primary mediators of functional connectivity among brain regions. However, the role of astrocyte-mediated communication has been largely underappreciated. While astrocytes communicate with one another through gap junctions, the extent and specificity of this communication remain poorly understood. Astrocyte gap junctions are necessary for memory formation

Identifiers

PMID40777296
PMCPMC12330634

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.