Evidence map›Paper›PMID 40777294›Full record

ArticlebioRxiv : the preprint server for biology2025

High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure.

Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen van de Wetering

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ibtesam RajparDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Nicholas YancyDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Jacob BeirigerDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Christina ShaoDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Syed NaqviDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Deana MancusoDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Fatemeh NiaziorimiDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.
Ryan E TomlinsonDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0002-6713-6047
Koen van de WeteringDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0003-1905-2743

Funding

The role of endogenous low molecular weight mineralization inhibitors in spine healthR01AR082460 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Makarand V Risbud, Koen van de Wetering · 2024 to 2026
$1.9M
Characterization of ENTPD1 as a drug target in PXER21AR083597 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI VAN DE WETERING, KOEN · 2023 to 2023
$378k
NIAMS NIH HHS R01 AR082460NIAMS NIH HHS R21 AR083597
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

calcificationciliary margineyemineralizationoral substitution therapyPPiPXEside effects

Identifiers

PMID40777294
PMCPMC12330526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.