Evidence map›Paper›PMID 40777288›Full record

ArticlebioRxiv : the preprint server for biology2025

BetaH proteolysis unleashes an electrostatic-homing antibacterial polymorphic toxin.

Daniel Mwangi, Maureen K Thomason, Lauren M Shull, Qing Tang, Joshua J Woodward

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Daniel MwangiDepartment of Microbiology, University of Washington, Seattle, WA 98109, USA.
Maureen K ThomasonDepartment of Microbiology, University of Washington, Seattle, WA 98109, USA.
Lauren M ShullDepartment of Microbiology, University of Washington, Seattle, WA 98109, USA.
Qing TangDepartment of Microbiology, University of Washington, Seattle, WA 98109, USA.
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, WA 98109, USA.

Funding

Listeria monocytogenes physiology and host pathogen interactionsR01AI116669 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2015 to 2024
$4.4M
C-di-AMP signaling in S. aureusR01AI139071 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2019 to 2023
$2.8M
NIAID NIH HHS R01 AI116669NIAID NIH HHS R01 AI139071
6 · The paper itself

Abstract

Contact-dependent or diffusible proteinaceous polymorphic toxin systems (PTSs) mediate widespread bacterial competition. While bioinformatic analyses have identified diverse PTSs across bacterial phyla, experimental validation in Gram-positive species remains limited. Here, we characterize a diffusible PTS encoded by the

Identifiers

PMID40777288
PMCPMC12330581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.