Evidence map›Paper›PMID 40777286›Full record

ArticlebioRxiv : the preprint server for biology2025

Impairment of neuronal activity occurs at the early stages of the aggregation cascade of Aβ

Franziska Hirsch, Nino Läubli, Anushree Kelkar, Mira Sleiman, Yvonne Woitzat, Christian Gallrein, Vanessa Gumz, Gurleen Kaur Kalsi, Ana Fernandez-Villegas, Gabriele Kaminski Schierle and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Franziska HirschDepartment of Cell Biology, University of Bremen, Leobener Strasse 2 28359 Bremen, Germany.
Nino LäubliMolecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa-Fawcett Drive Cambridge, CB3 0AS, UK.ORCID 0000-0003-2894-2385
Anushree KelkarLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Mira SleimanLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Yvonne WoitzatLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Christian GallreinLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Vanessa GumzLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Gurleen Kaur KalsiLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.
Ana Fernandez-VillegasMolecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa-Fawcett Drive Cambridge, CB3 0AS, UK.
Gabriele Kaminski SchierleMolecular Neuroscience Group, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa-Fawcett Drive Cambridge, CB3 0AS, UK.
Janine KirsteinLeibniz Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11 07745 Jena, Germany.ORCID 0000-0003-4990-2497

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440Wellcome Trust
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary Tau tangles, ultimately leading to brain atrophy and death. To elucidate the relationship between the aberrant folding and aggregation of Aβ and mutant Tau and neuronal function, we monitored neuronal activity in

Identifiers

PMID40777286
PMCPMC12330732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.