Evidence map›Paper›PMID 40777274›Full record

ArticlebioRxiv : the preprint server for biology2025

Charting structural brain asymmetry across the human lifespan.

Lena Dorfschmidt, Simon White, Margaret Gardner, Saashi Bedford, Gareth Ball, A David Edwards, Yuanjun Gu, Yuankai He, Hao Huang, Shivaram Karandikar and 24 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Lena DorfschmidtLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.ORCID 0000-0002-0447-1104
Simon WhiteDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8642-7037
Margaret GardnerLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.
Saashi BedfordDepartment of Psychology, University of Cambridge, Cambridge, UK.
Gareth BallDevelopmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.ORCID 0000-0003-3509-1435
A David EdwardsDepartment of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID 0000-0003-4801-7066
Yuanjun GuDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Yuankai HeDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0212-6670
Hao HuangDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Shivaram KarandikarLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.
Vanessa KyriakopoulouResearch Department of Biomedical Computing, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Minhui OuyuangDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Elmo P PulliFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Armin RaznahanSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, 20892, USA.
Emma C RobinsonResearch Department of Biomedical Computing, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Rafael Romero-GarcíaDepartment of Medical Physiology and Biophysics, University of Seville; Seville, Spain.
Theodore D SatterthwaiteLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.ORCID 0000-0001-7072-9399
Jenna SchabdachLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.
Isaac SebeniusDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Zhiqiang ShaLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania.
Jetro TuulariClinical Neurosciences, University of Turku, Turku, Finland.
Matilde M VaghiSchool of Psychological Sciences, Birkbeck University of London, London, UK.ORCID 0000-0002-0999-9055
Jacob VogelDepartment of Clinical Sciences, SciLifeLab, Lund University, Lund, Sweden.ORCID 0000-0001-6394-9940
František VášaDepartment of Neuroimaging, King's College London, London, UK.
Logan WilliamsResearch Department of Biomedical Computing, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Dabriel ZimmermanLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.ORCID 0000-0002-8848-5449
Lifespan Brain Chart Consortium
Varun WarrierDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4532-8571
Konrad WagstylResearch Department of Biomedical Computing, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Edward T BullmoreDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8955-8283
Richard A I BethlehemDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0714-0685
Jakob SeidlitzLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.ORCID 0000-0002-8164-7476
Aaron Alexander-BlochLifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia PA 19139, USA.ORCID 0000-0001-6554-1893

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)U19NS120384 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Kumar B. Rajan · 2020 to 2026
$61.9M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAGIER-TOURENNE, CLOTILDE · 1985 to 2018
$55.4M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
NCATS NIH HHS UL1 TR000448NCRR NIH HHS U24 RR021382NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG012435NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062428NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG021910NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG045571NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG052560NIA NIH HHS R01 AG053509NIA NIH HHS R01 AG053993NIA NIH HHS R01 AG054110NIA NIH HHS R01 AG055005NIA NIH HHS R01 AG056031NIA NIH HHS R01 AG056258NIA NIH HHS R01 AG056531NIA NIH HHS R01 AG058724NIA NIH HHS R01 AG061788NIA NIH HHS R01 AG062276NIA NIH HHS R01 AG067781NIA NIH HHS R01 AG068338NIA NIH HHS R01 AG069453NIA NIH HHS R01 AG073235NIA NIH HHS R01 AG077444NIA NIH HHS R35 AG072262NIA NIH HHS R56 AG045571NIA NIH HHS R56 AG074321NIA NIH HHS RC2 AG036547NIA NIH HHS RF1 AG057473NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG057195NIA NIH HHS U01 AG061356NIA NIH HHS U19 AG063911NIA NIH HHS U19 AG073153NIA NIH HHS U24 AG067418NIA NIH HHS U24 AG072122NIBIB NIH HHS R01 EB009352NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIDCD NIH HHS R01 DC008552NIDCD NIH HHS R01 DC016385NIH HHS S10 OD026738NIMH NIH HHS P50 MH071616NIMH NIH HHS P50 MH081755NIMH NIH HHS R01 MH036840NIMH NIH HHS R01 MH104324NIMH NIH HHS R01 MH110558NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH132934NIMH NIH HHS R01 MH133843NIMH NIH HHS R01 MH134896NIMH NIH HHS R21 MH107045NIMH NIH HHS U01 MH108898NIMH NIH HHS U01 MH109977NIMH NIH HHS U01 MH110274NIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629NIMH NIH HHS U54 MH091657NINDS NIH HHS P30 NS098577NINDS NIH HHS R01 NS075075NINDS NIH HHS U19 NS120384NINDS NIH HHS U24 NS130411RRD VA I01 RX001534RRD VA I21 RX001381Wellcome Trust
6 · The paper itself

Abstract

Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodevelopmental and neurodegenerative disorders. Here, we present a normative framework for benchmarking brain asymmetry across the lifespan, developed from an aggregated sample of 128 primary neuroimaging studies, including 177,701 scans from 138,231 individuals, jointly spanning the age range from 20 post menstrual weeks to 102 years. This resource includes comprehensive, hemisphere-specific brain growth charts for multiple neuroimaging phenotypes: regional cortical grey matter volume, thickness, surface area, and subcortical volumes. Our findings reveal distinct spatial patterns of asymmetry, with early leftward asymmetry observed in association cortices and late rightward asymmetry in sensory regions. These trajectories support theories of the neuroplasticity of asymmetry and the role of both genetic and environmental factors in shaping brain lateralization. Additionally, we provide tools to generate asymmetry centile scores, which allow the quantification of individual deviations from typical asymmetry throughout the lifespan and can be applied to unseen data or clinical populations. We demonstrate the utility of these models by highlighting group-level differences in asymmetry in autism spectrum disorder, schizophrenia, and Alzheimer's disease, and exploring genetic correlations with hemispheric specialization. To facilitate further research, we have made this normative framework freely available as an interactive open-access resource (upon publication), offering an essential tool to advance both basic and clinical neuroscience.

Identifiers

PMID40777274
PMCPMC12330520

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.