Evidence map›Paper›PMID 40777273›Full record

ArticlebioRxiv : the preprint server for biology2025

A Lung Tumor-on-a-Chip Model Recapitulates the Effect of Hypoxia on Radiotherapy Response and FDG-PET Imaging.

Rohollah Nasiri, Myra Kurosu Jalil, Veronica Ibanez Gaspar, Andrea Sofia Flores Perez, Hieu Thi Minh Nguyen, Syamantak Khan, Sindy Ky Tang, Yunzhi Peter Yang, Guillem Pratx

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rohollah NasiriDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8245-692X
Myra Kurosu JalilDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9363-4592
Veronica Ibanez GasparDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Andrea Sofia Flores PerezDepartment of Bioengineering, 443 Via Ortega, Stanford University School of Engineering, Stanford, CA 94305, USA.
Hieu Thi Minh NguyenDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Syamantak KhanDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5864-1842
Sindy Ky TangDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1465-2432
Yunzhi Peter YangDepartment of Bioengineering, 443 Via Ortega, Stanford University School of Engineering, Stanford, CA 94305, USA.ORCID 0000-0002-3891-0574
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0247-6470

Funding

Preclinical microphysiological tumor models for nuclear medicineR01CA268514 · NCI · STANFORD UNIVERSITY · PI Guillem Pratx, JOHN B SUNWOO · 2023 to 2026
$2.1M
NCI NIH HHS R01 CA268514
6 · The paper itself

Abstract

Most solid tumors contain regions of hypoxia that pose a significant challenge to the efficacy of radiation therapy. This study introduces a novel 3D lung tumor-on-a-chip (ToC) model designed to replicate the hypoxic tumor microenvironment

Indexed as

FDGhypoxiaMicrofluidicsPET imagingradiation therapyRLM microscopytumor microenvironmenttumor-on-a-chip

Identifiers

PMID40777273
PMCPMC12330578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.