ArticlebioRxiv : the preprint server for biology2025
The Dream and MEC NuRD Complexes reinforce SPR-5/MET-2 maternal reprogramming to maintain the germline-soma distinction.
Sindy R Chavez, Jazmin Dozier, Saahj P Gosrani, Sandra K Nguyen, Jovan S Brockett, Sarah D Blancher, Sydney L Morgan-Benitez, Juan D Rodriguez, Onur Birol, Monica N Reeves and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Sindy R ChavezDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.
Jazmin DozierDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Saahj P GosraniDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.
Sandra K NguyenDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Jovan S BrockettDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.ORCID 0000-0002-0665-553X Sarah D BlancherDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Sydney L Morgan-BenitezDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Juan D RodriguezDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.
Onur BirolNatural Sciences Division, Oglethorpe University, Atlanta GA 30319, USA.
Monica N ReevesDepartment of Cell Biology, Emory University School of Medicine, Atlanta GA 30322, USA.
Karen L SchmeichelSchool of Biological Sciences, Georgia Institute of Technology, Atlanta GA 30332, USA.ORCID 0000-0001-8078-5335 Brandon S CarpenterDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.ORCID 0000-0001-9939-1926 Funding
IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2MThe Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MTraining In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9MGenetics Predoctoral Training ProgramT32GM149422 · NIGMS · EMORY UNIVERSITY · PI TAMARA J. CASPARY · 2023 to 2026
$2.2MAlzheimer's Disease Big Data to Biology Training Program (ADBDB-TP)T32AG087922 · NIA · EMORY UNIVERSITY · PI Todd E Golde, DAVID WEINSHENKER · 2024 to 2026
$1.7MU-RISE at Kennesaw StateT34GM140948 · NIGMS · KENNESAW STATE UNIVERSITY · PI GRIFFIN, MELANIE CHRISTINE, HUDSON, MARTIN LYN · 2022 to 2024
$692kElucidating the mechanisms by which ectopically expressed genes and piRNAs perturb somatic cell function when histone methylation is inappropriately regulatedR15GM148887 · NIGMS · KENNESAW STATE UNIVERSITY · PI CARPENTER, BRANDON SCOTT · 2023 to 2023
$432kThe effect of age on epigenetic reprogramming in C.elegansF32HD097920 · NICHD · EMORY UNIVERSITY · PI BIROL, ONUR · 2019 to 2021
$168kRegulation of embryonic cell fate decision by histone methylationF31HD100145 · NICHD · EMORY UNIVERSITY · PI RODRIGUEZ, JUAN D · 2019 to 2023
$162kNIA NIH HHS P30 AG066511NIA NIH HHS T32 AG087922NICHD NIH HHS F31 HD100145NICHD NIH HHS F32 HD097920NIGMS NIH HHS K12 GM000680NIGMS NIH HHS R15 GM148887NIGMS NIH HHS T32 GM008490NIGMS NIH HHS T32 GM149422NIGMS NIH HHS T34 GM140948NIH HHS P40 OD010440NINDS NIH HHS T32 NS096050
6 · The paper itselfAbstract
The proper coordination of transcription factors, ATP dependent chromatin remodelers and histone modifications is essential for tissue specific gene expression, but how gene expression is regulated at these different levels is not well understood. In
Indexed as
developmental delayDream Complexepigeneticshistone methylationLIN-35maternal reprogrammingMEC ComplexMEP-1transgenerational inheritance
Identifiers
PMID40777264
PMCPMC12330697
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