Evidence map›Paper›PMID 40777263›Full record

ArticlebioRxiv : the preprint server for biology2026

Isoform-Specific Control of Adipose Thermogenesis by the miR-27 Family Reveals Antagonism within a Polycistronic miRNA Cluster.

Devesh Kesharwani, Michele Karolak, Chad C Doucette, Eric R Loomis, Sophia E Adami-Sampson, Su Su, Victoria DeMambro, Clifford Rosen, Anne Harington, Larisa Ryzhova and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Devesh KesharwaniCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.ORCID 0000-0001-6940-3703
Michele KarolakCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Chad C DoucetteCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Eric R LoomisCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Sophia E Adami-SampsonCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Su SuCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Victoria DeMambroCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Clifford RosenCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Anne HaringtonCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Larisa RyzhovaCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Lucy LiawCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.
Aaron C BrownCenter for Molecular Medicine, MaineHealth Institute for Research, 81 Research Drive, Scarborough, ME 04074.ORCID 0000-0003-0827-2337

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI Lucy Liaw · 2017 to 2026
$25.1M
miR-27 mediated regulation of mitochondrial function in thermogenic adipocytesR01DK124261 · NIDDK · MAINEHEALTH · PI BROWN, AARON CLIFFORD · 2021 to 2025
$2.1M
NIDDK NIH HHS R01 DK124261NIGMS NIH HHS P20 GM121301NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are frequently encoded within polycistronic clusters thought to function as coherent regulatory units, yet whether individual cluster members act cooperatively or exert distinct physiological effects remains unclear. miR-27a and miR-27b are closely related miRNAs located within separate paralogous miR-23/27/24 clusters, but their

Indexed as

adipose tissueCRISPR knockoutmetabolismmicroRNA clustersmiR-27obesitythermogenesis

Identifiers

PMID40777263
PMCPMC12330670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.