Evidence map›Paper›PMID 40777251›Full record

ArticlebioRxiv : the preprint server for biology2025

SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma.

Hayk Mnatsakanyan, Alessandro Sammarco, Rami Awwad, Abigail Hewett, Elie Roumieh, Caline Pechdimaljian, Yana Azar, Richa Pradhan, Baolong Su, Kevin J Williams and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Hayk MnatsakanyanDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Alessandro SammarcoDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Rami AwwadDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Abigail HewettDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Elie RoumiehDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Caline PechdimaljianDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Yana AzarDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Richa PradhanDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Baolong SuUCLA Lipidomics Laboratory, University of California, Los Angeles, CA, USA.
Kevin J WilliamsUCLA Lipidomics Laboratory, University of California, Los Angeles, CA, USA.
Steven J BensingerDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Christian E BadrDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7212-5975

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5M
Role of ER Stress and Fatty Acid Metabolism in Glioma Stem CellsR01NS113822 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BADR, CHRISTIAN ELIAS · 2020 to 2024
$2.0M
NCI NIH HHS P50 CA165962NINDS NIH HHS R01 NS113822
6 · The paper itself

Abstract

Glioblastoma (GBM) relies on fatty acid metabolism to sustain its aggressive growth. While the role of stearoyl-CoA desaturase-1 (SCD1) in GBM is established, the function of its brain-enriched isoform, SCD5, remains unexplored. Here, we demonstrate that SCD5 is essential for glioblastoma stem cell (GSC) maintenance and genomic stability, with elevated expression in GSCs that declines upon differentiation, underscoring its role in tumor initiation. Through shotgun lipidomics,

Identifiers

PMID40777251
PMCPMC12330519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.