Evidence map›Paper›PMID 40777179›Full record

ArticleFrontiers in nutrition2025

Xihua Yu, Liming Huang, Yi Wang, Liuruolan Li, Wenwei Lu, Zhijian Zhang, Hongchao Wang

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Frontiers in nutrition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xihua YuSinopharm Xingsha Pharmaceutical (Xiamen) Co., Ltd., Xiamen, Fujian, China.
Liming HuangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China.
Yi WangSinopharm Xingsha Pharmaceutical (Xiamen) Co., Ltd., Xiamen, Fujian, China.
Liuruolan LiSinopharm Xingsha Pharmaceutical (Xiamen) Co., Ltd., Xiamen, Fujian, China.
Wenwei LuState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China.
Zhijian ZhangDepartment of Nephrology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, China.
Hongchao WangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with increasing global prevalence, making it a significant health concern. Although vitamin A (VA) plays a beneficial role in UC management, its therapeutic efficacy is limited by impaired absorption and disrupted retinoic acid (RA) metabolism. Gut microbiota are known to influence VA metabolic pathways, offering potential targets to enhance VA bioavailability and efficacy. Methods: A dextran sulphate sodium (DSS)-induced mouse model of colitis was established to evaluate the therapeutic effects of co-administering Results: It was indicated that the VA and CCFM1426 combination significantly improved colon length and DAI, enhanced serum levels of intestinal injury markers (lipopolysaccharide-binding protein, intestinal fatty acid-binding protein, diamine oxidase) and cytokines (IL-6, TNF- Conclusion: These findings provide novel evidence that co-administration of CCFM1426 and VA synergistically alleviates colitis by enhancing RA bioavailability through microbiota-dependent pathways.

Indexed as

Bifidobacterium longum subsp. infantisgut microbiotaretinoic acidulcerative colitisvitamin A

Identifiers

PMID40777179
PMCPMC12330391

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.