ReviewFrontiers in nutrition2025
Role of micronutrition in patients with oral cancer and nutritional intervention strategies.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Vitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms.Journal of clinical medicine · 2026Review
- Cancer-Related Malnutrition and Oxidative Stress in Colorectal Cancer Surgery: A Narrative Review of Pathophysiology and Postoperative Outcomes.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cavity cancer exhibits high mortality rates with conventional therapies often causing nutritional complications. Emerging evidence highlights the critical role of micronutrients in modulating oxidative stress, a key driver of carcinogenesis in precancerous lesions including oral lichen planus, leukoplakia and submucous fibrosis. Zinc deficiency impairs antioxidant defenses while copper excess promotes angiogenesis. Selenium maintains redox balance through selenoproteins and vitamins A, E and C exhibit chemopreventive effects through reactive oxygen species scavenging and immunomodulation. Immunonutrition strategies incorporating omega-3 fatty acids and arginine demonstrate benefits in postoperative outcomes. This review summarizes the mechanistic roles of antioxidant micronutrients including zinc, copper, selenium and vitamins A, D, E, C and B complex in oral squamous cell carcinoma pathogenesis and explores personalized nutritional interventions to enhance treatment tolerance and quality of life. Optimizing micronutrient status represents a promising adjuvant approach in comprehensive oral cancer management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.