ArticleCureus2025
Regenerative Management of a Late Endoperiodontal Complication After Phased Perio-Orthodontic Therapy: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A man in his mid-50s with stage III periodontitis underwent a structured, multiphase treatment. Following the initial therapy that achieved periodontal stability (evidenced by improved clinical parameters), orthodontic treatment with strategic extractions was performed. Unexpectedly, a severe endoperiodontal lesion subsequently developed in the left maxillary canine. Cone-beam CT confirmed extensive circumferential bone resorption. After endodontic therapy, periodontal regenerative therapy using enamel matrix derivative and bovine bone graft was performed. Six months post-surgery, the probing pocket depth improved from 6 mm to 3 mm, with no bleeding on probing, and radiographs showed improved radiopacity. A 2.5-year follow-up demonstrated a stable periodontal condition. This case underscores that late-stage complications can arise even with thorough evidence-based therapy. This highlights the importance of proactive monitoring and demonstrates the potential for successful regeneration of severe bone defects.
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