Evidence map›Paper›PMID 40777047›Full record

ArticleiScience2025

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice.

Farah Issa, Xavier Yerna, Thibaud Parpaite, Caren Jabbour, Olivier Schakman, Nicolas Tajeddine, Roberta Gualdani, Philippe Gailly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Farah IssaUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Xavier YernaUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Thibaud ParpaiteUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Caren JabbourUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Olivier SchakmanUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Nicolas TajeddineUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Roberta GualdaniUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.
Philippe GaillyUniversity of Louvain - Institute of Neuroscience - Laboratory of Cell Physiology, 1200 Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal ion channel, as a key mGluR5 effector. Using a Cre-tamoxifen system, we acutely deleted

Indexed as

GeneticsMolecular biologyNeuroscience

Identifiers

PMID40777047
PMCPMC12329558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.