Evidence map›Paper›PMID 40777015›Full record

ArticleFrontiers in immunology2025

CREB regulates Foxp3

Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Saskia Schulz, Thomas Look, Tannaz Goodarzi, Tim Clarner, Miriam Scheld, Markus Kipp, Eva Verjans, Svenja Böll and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Sudheendra Hebbar SubramanyamDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Judit Turyne HriczkoDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Saskia SchulzDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Thomas LookHelmholtz-Institute for Biomedical Engineering, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Tannaz GoodarziDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Tim ClarnerInstitute of Neuroanatomy and Jülich Aachen Research Alliance (JARA)-BRAIN, Faculty of Medicine, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Miriam ScheldInstitute of Neuroanatomy and Jülich Aachen Research Alliance (JARA)-BRAIN, Faculty of Medicine, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Markus KippInstitute of Anatomy, Medical University of Rostock, Rostock, Germany.
Eva VerjansDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Svenja BöllDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Christopher NeullensDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Ivan CostaInstutute for Computational Genomics, Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Zhijian LiInstutute for Computational Genomics, Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Lin GanGenomics Facility, Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Bernd DeneckeGenomics Facility, Interdisciplinary Center for Clinical Research Aachen (IZKF Aachen), Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Angela SchippersDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Stefan FloessDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Jochen HuehnDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Edgar SchmittInstitute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Tobias BoppInstitute for Immunology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Hermann WasmuthDepartment of Medicine, Luiusenhospital Aachen, Aachen, Germany.
Ron WinogradDepartment of Medicine, Luiusenhospital Aachen, Aachen, Germany.
Rudi BeyaertVlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research, Ghent, Belgium.
Bart LambrechtVlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research, Ghent, Belgium.
Martin ZenkeHelmholtz-Institute for Biomedical Engineering, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Norbert WagnerDepartment of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Kim Ohl *Department of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.
Klaus Tenbrock *Department of Pediatrics, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Regulatory T-cells (T Methods: T Results and discussion:

Indexed as

Cyclic AMP Response Element-Binding ProteinForkhead Transcription FactorsInterleukin-10Interleukin-1 Receptor-Like 1 ProteinT-Lymphocytes, RegulatoryAnimalsColitisMiceMice, Inbred C57BLMice, KnockoutCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinForkhead Transcription FactorsFoxp3 protein, mouseIL10 protein, mouseIl1rl1 protein, mouseInterleukin-10Interleukin-1 Receptor-Like 1 ProteinCREBCREMFoxp3IL-10IL-33ST2

Identifiers

PMID40777015
PMCPMC12328323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.