Evidence map›Paper›PMID 40777005›Full record

ArticleFrontiers in immunology2025

Decoupled dynamics of absolute and relative lymphocyte counts and age-polarized CD4

Ting Ge, Guixin He, Qian Cui, Shuangcui Wang, Zekun Wang, Yingying Xie, Yuanyuan Tian, Juyue Zhou, Wentao Li, Baohui Wang and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ting Ge *Central Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Guixin He *Central Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Qian CuiCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shuangcui WangCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zekun WangDepartment of Biostatistics, School of Global Public Health, New York University, New York, NY, United States.
Yingying XieCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yuanyuan TianCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Juyue ZhouCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wentao LiNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Baohui WangThe First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou, China.
Keming ZhangDepartment of Nutrition, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jianchun YuCentral Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Significant phenotypic and functional differences in peripheral lymphocyte subsets between infants and the elderly contribute to age-related variations in disease susceptibility and clinical outcomes. However, we are unable to specifically analyze the underlying causes owing to a lack of data on lymphocyte absolute counts and functional markers from two extremes of age. Methods: A total of 111 infants (≤ 6 months) and 111 older adults (≥ 65 years) were enrolled to assess the percentages and absolute counts of peripheral blood lymphocyte (PBL) subsets. These included CD3 Results: Comparative analysis demonstrated that infants had significantly higher absolute counts of CD3 Conclusion: PBL profiles exhibit marked heterogeneity at the extremes of age, with infants showing abundant naïve and memory T cell reserves, while older adults are characterized by increased NK cell activity. The age-dependent polarization of the CD4

Indexed as

AgingCD4-CD8 RatioCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAgedAged, 80 and overAge FactorsFemaleHumansImmunophenotypingInfantLymphocyte CountMaleT-Lymphocyte Subsetsabsolute countsCD4 +/CD8 + ratioinfantsolder adultsperipheral blood lymphocyte subsets

Identifiers

PMID40777005
PMCPMC12328443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.