Evidence map›Paper›PMID 40777003›Full record

ArticleFrontiers in immunology2025

Photopharmacology reveals high-specificity linkage of Ca

Denis Krivić, Olga Panasiuk, Johannes Pilic, Roland Malli, Bernadett Bacsa, Sanja Ćurčić, Klaus Groschner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denis KrivićDivision of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Olga PanasiukDivision of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Johannes PilicDivision of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Roland MalliCore Facility Bioimaging, Center for Medical Research, Medical University of Graz, Graz, Austria.
Bernadett BacsaDivision of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Sanja ĆurčićDivision of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Klaus GroschnerDivision of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Photopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model. Results: Expression of TRPC6 fusion constructs in RBL-2H3 allowed for generation of temporally well-defined, cytosolic Ca Conclusion: We report here the exceptionally efficient and specific modulation of mast cell activity by TRPC6 photopharmacology.

Indexed as

CalciumCalcium SignalingMast CellsNFATC Transcription FactorsTRPC6 Cation ChannelAnimalsCell DegranulationCell LineHumansRatsUltraviolet RaysCalciumNFATC Transcription FactorsTRPC6 Cation ChannelbasophilsCa2+-transcription couplingmast cellsNFATc1photopharmacologyTRPC6

Identifiers

PMID40777003
PMCPMC12329589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.