ArticleThe journal of allergy and clinical immunology. Global2025
Objective sensitization algorithm validates parental report of food allergy in children.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The criterion standard to diagnose food allergy includes oral food challenge, which is expensive, carries some risk, and is often not feasible in large research cohort studies. Data regarding subjective food allergy screening tools such as parental report of physician-diagnosed food allergy have not been validated. Objective: We sought to determine the level of agreement between parental report of physician-diagnosed food allergy and a food allergy algorithm diagnostic tool that uses objective sensitization markers in children. Methods: We utilized longitudinal data that were collected from the Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH) early-life cohort over 4 annual visits to determine the association between parental report of food allergy and food allergy diagnosis using a food allergy algorithm based on a validated tool. Results: Of a total of 671 participants, 563 were included in this study; 88 children were excluded because they did not have questionnaire and algorithm data for all 4 visits. A total of 6972 evaluations focusing on milk, egg, peanut, tree nuts, wheat, and soy were conducted. Compared with the food allergy algorithm, parental report of physician-diagnosed food allergy had a positive predictive value of 64.5% and a negative predictive value of 99.1%. The overall agreement did not differ substantially over time for the top 3 food allergens. Conclusion: Parental report of physician-diagnosed food allergy can accurately determine children without food allergy; however, food allergy will likely be overestimated if a positive response is used to identify food allergy.
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