ArticleFrontiers in medicine2025
The impact of IGRA positivity in untreated inactive pulmonary tuberculosis on IVF-ET outcomes in infertile women: an ambispective cohort study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between latent tuberculosis infection and assisted reproductive outcomes: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Adverse clinical outcomes in patients with good ovarian reserve are linked to a history of cured tuberculosis: a retrospective cohort study.Reproductive health · 2026Article
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Authors and funding
15 authors.
Funding
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Abstract
Background: Tuberculosis can negatively impact both overall health and female reproductive function. This study investigated the relationship between the interferon-gamma release assay (IGRA) status and pregnancy outcomes in infertile women, with untreated "inactive" tuberculosis lesions observed on chest radiography, who are undergoing Methods: This ambispective cohort study, which includes retrospective (2012-2019) and prospective (2020-2024) cohorts, enrolled infertile women with untreated inactive tuberculosis lesions visible on chest imaging who are planning to undergo IVF-ET. All patients underwent IGRA testing. Baseline characteristics, such as age, body mass index (BMI), infertility factors, ultrasound follicle count, and hormone levels, were collected. Pregnancy outcomes, including live birth rates, oocyte retrieval numbers, embryo quality, clinical pregnancy, miscarriage, and preterm birth rates, were followed and compared between the IGRA-positive and IGRA-negative groups. Results: Among 836 patients, the IGRA positivity rate was 42.5%. The cumulative miscarriage rate was higher in the IGRA-positive group than in the IGRA-negative group (21.5% vs. 15.0%, Conclusion: In infertile women with untreated inactive tuberculosis lesions on chest radiography, IGRA positivity is associated with higher cumulative miscarriage rates following IVF-ET. Early IGRA screening and intervention may help improve pregnancy outcomes.
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