Evidence map›Paper›PMID 40776909›Full record

ArticleFrontiers in medicine2025

Case Report: Genetic predisposition to low-dose NSAID-induced liver injury in real-world China.

Yuan Lyu, Yangjie Li, Yingying Jiang, Qi Li, Chen Shao, Chunlei Fan, Ying Han, Hui Liu, Lingna Lyu, Huiguo Ding

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Herb-Induced Liver Injury byLife (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan Lyu *Laboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Yangjie Li *Laboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Yingying JiangLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Qi LiLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Chen ShaoLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Chunlei FanLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Ying HanLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Hui LiuLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Lingna LyuLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.
Huiguo DingLaboratory for Clinical Medine, Department of Gastroenterology and Hepatology, Capital Medical University, Beijing You'an Hospital, Affiliated to Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-steroidal anti-inflammatory drug (NSAID)-induced liver injury represents approximately 10% of reported drug-induced liver injury (DILI) cases, predominantly through idiosyncratic mechanisms. While epidemiological data are largely derived from Western populations with high NSAID utilization, China exhibits lower use of NSAIDs due to cultural preferences and the widespread use of traditional therapies. During the 2022-2023 Omicron outbreak in China, we observed a surge in DILI cases coinciding with increased NSAID use. This study reports two young male patients who developed severe cholestatic DILI following low-dose ibuprofen intake (400 mg), despite lacking conventional risk factors. Genetic analysis revealed compound heterozygous mutations in

Indexed as

BSEP (ABCB11)drug-induced liver injurygenetic predispositionibuprofennon-steroidal anti-inflammatory drugs

Identifiers

PMID40776909
PMCPMC12328316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.