Evidence map›Paper›PMID 40776881›Full record

Observational studyHypertension (Dallas, Tex. : 1979)2025

Lower Prepregnancy Cardiovascular Health is Associated With Hypertensive Disorders of Pregnancy: The CARDIA Study.

Leah V Dodds, Daniel J Feaster, Catarina I Kiefe, Erica P Gunderson, Natalie A Bello, Tatjana Rundek, Michael J Paidas, Shathiyah Kulandavelu, Tali Elfassy

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leah V DoddsDepartment of Public Health Sciences (L.V.D., D.J.F.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0002-8155-8131
Daniel J FeasterDepartment of Public Health Sciences (L.V.D., D.J.F.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0002-6172-7460
Catarina I KiefeDepartment of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA (C.I.K.).
Erica P GundersonBernard J Tyson Kaiser Permanente School of Medicine, Pasadena, CA (E.P.G.).ORCID 0000-0002-2039-1964
Natalie A BelloSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (N.A.B.).ORCID 0000-0003-3257-3623
Tatjana RundekDepartment of Neurology, Evelyn F. McKnight Brain Institute (T.R.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0002-7115-9815
Michael J PaidasDepartment of Obstetrics, Gynecology, and Reproductive Sciences (M.P.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0001-5561-7196
Shathiyah KulandaveluDepartment of Pediatrics and Interdisciplinary Stem Cell Institute (S.K.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0003-0966-7613
Tali ElfassyKatz Family Division of Nephrology and Hypertension (T.E.), University of Miami Miller School of Medicine, Miami, FL.ORCID 0000-0002-7528-7988

Funding

CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - COORDINATING CENTER (CC)75N92023D00002 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, JING · 2023 to 2025
$6.8M
Lactation and Incidence of Diabetes Mellitus in CARDIA WomenR01DK090047 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GUNDERSON, ERICA PAULINE · 2011 to 2014
$2.7M
Pregnancy-Related Risk Factors and Glucose Intolerance in Women during MidlifeR01DK106201 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GUNDERSON, ERICA PAULINE · 2015 to 2018
$2.7M
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - OAKLAND FIELD CENTER75N92023D00003 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI BHATT, ANKEET S. · 2023 to 2025
$2.2M
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - BIRMINGHAM FIELD CENTER75N92023D00005 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA · 2023 to 2025
$2.2M
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - CHICAGO FIELD CENTERDIVERSITY SUPPLEMENT FOR MORGANN WEST75N92023D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI CARNETHON, MERCEDES · 2023 to 2025
$2.1M
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - UNIVERSITY OF MINNESOTA FIELD CENTER.75N92023D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI SCHREINER, PAMELA J · 2023 to 2025
$1.7M
Understanding drivers of incident hypertension disparities among US Hispanics of diverse backgroundsK01MD014158 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELFASSY, TALI · 2019 to 2022
$645k
Hypertensive Disorders of Pregnancy – The Black/White DisparityF31HL165894 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Leah Verna Dodds · 2023 to 2026
$216k
NHLBI NIH HHS 75N92023D00002NHLBI NIH HHS 75N92023D00003NHLBI NIH HHS 75N92023D00004NHLBI NIH HHS 75N92023D00005NHLBI NIH HHS 75N92023D00006NHLBI NIH HHS F31 HL165894NIDDK NIH HHS R01 DK090047NIDDK NIH HHS R01 DK106201NIMHD NIH HHS K01 MD014158
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia, and eclampsia, contribute to increased maternal morbidity and mortality and long-term cardiovascular disease risk. It is unclear whether HDP arises from pregnancy-specific complications or preexisting maternal cardiovascular traits unmasked during pregnancy. This article evaluates whether cardiovascular health before pregnancy, assessed by the American Heart Association's Life's Essential 8 (LE8) score, is associated with HDP risk.

methodsThe CARDIA (Coronary Artery Risk Development in Young Adults) is a longitudinal cohort study of 5115 Black and White men and women, aged 18 to 30 years at baseline (1985-1986), and followed for over 30 years (n

resultsMean baseline age was 24.1 years, 48.7% were Black women, and 19.9% reported HDP. Women with HDP had lower baseline LE8 scores (77.0 versus 79.5;

conclusionsLower prepregnancy cardiovascular health is an independent risk factor for HDP. Improving cardiovascular health may reduce HDP risk.

Indexed as

Cardiovascular DiseasesHypertension, Pregnancy-InducedAdolescentAdultBlood PressureFemaleHumansLongitudinal StudiesMalePregnancyRisk FactorsUnited StatesYoung Adultcardiovascular diseasescardiovascular healthhypertension, pregnancy-inducedpreconceptionpreeclampsiaprepregnancy

Identifiers

PMID40776881
PMCPMC12372538

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.