Evidence map›Paper›PMID 40776860›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Redefining AT1 Receptor PET Imaging: Introducing the Radiotracer [

Xinyu Chen, Hiroyuki Kimura, Takanori Sasaki, Konrad Klimek, Saskia Mühlig, Anahi Paula Arias-Loza, Naoko Nose, Yusuke Yagi, Steven P Rowe, Constantin Lapa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Transient Increase in ATInternational journal of molecular sciences · 2026
    Article
  2. Enabling Noninvasive Visualization of AT1R Through a NewHypertension (Dallas, Tex. : 1979) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xinyu ChenNuclear Medicine, Faculty of Medicine, University of Augsburg, Germany (X.C., C.L.).ORCID 0000-0002-6165-1689
Hiroyuki KimuraAgency for Health, Safety and Environment, Kyoto University, Japan (H.K.).
Takanori SasakiFaculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan (T.S., N.N., Y.Y., T.H.).ORCID 0000-0002-0821-827X
Konrad KlimekGoethe University Frankfurt, University Hospital, Clinic for Radiology and Nuclear Medicine, Department of Nuclear Medicine, Germany (K.K.).
Saskia MühligDepartment of Nuclear Medicine and Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Germany (S.M., A.P.A.-L., T.H.).ORCID 0009-0002-7494-7507
Anahi Paula Arias-LozaDepartment of Nuclear Medicine and Comprehensive Heart Failure Center (DZHI), University Hospital Würzburg, Germany (S.M., A.P.A.-L., T.H.).ORCID 0000-0003-4048-4719
Naoko NoseFaculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan (T.S., N.N., Y.Y., T.H.).
Yusuke YagiFaculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan (T.S., N.N., Y.Y., T.H.).ORCID 0000-0003-0937-3746
Steven P RoweMolecular Imaging and Therapeutics, Department of Radiology, School of Medicine, University of North Carolina, Chapel Hill, NC (S.P.R.).
Constantin LapaNuclear Medicine, Faculty of Medicine, University of Augsburg, Germany (X.C., C.L.).
Rudolf A Werner *Department of Nuclear Medicine, LMU Hospital, Ludwig-Maximilians-University of Munich, Germany (R.A.W.).ORCID 0000-0003-3372-6046
Takahiro Higuchi *Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan (T.S., N.N., Y.Y., T.H.).ORCID 0000-0001-9711-7835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAT1R (angiotensin II type 1 receptors) are central to the renin-angiotensin system and are involved in regulating blood pressure and renal physiology. This study introduces [

methodsRadiolabeling was established, and biodistribution studies were conducted on healthy Wistar rats with and without the AT1R antagonist candesartan and transporter inhibitors. Dynamic positron emission tomography imaging assessed tracer specificity, and feasibility for renal AT1R quantification was explored using a hypertensive rat model.

results[

conclusionsThese results support [

Indexed as

Fluorine RadioisotopesHypertensionKidneyPositron-Emission TomographyReceptor, Angiotensin, Type 1Angiotensin II Type 1 Receptor BlockersAnimalsBenzimidazolesBiphenyl CompoundsDisease Models, AnimalMaleRadiopharmaceuticalsRatsRats, WistarRenin-Angiotensin SystemTetrazolesAngiotensin II Type 1 Receptor BlockersBenzimidazolesBiphenyl CompoundscandesartanFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsReceptor, Angiotensin, Type 1Tetrazolesangiotensin II type 1 receptororganic anion transportersorganic anion transporting polypeptidesrenal imagingrenin-angiotensin system

Identifiers

PMID40776860
PMCPMC12440281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.