Evidence map›Paper›PMID 40776790›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Longitudinal associations between plasma biomarkers and changes in naturalistic driving behaviors in older adults.

Chen Chen, Ganesh M Babulal

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chen ChenDepartment of Neurology, School of Medicine, Washington University, St Louis, MO, USA.
Ganesh M BabulalDepartment of Neurology, School of Medicine, Washington University, St Louis, MO, USA.ORCID 0000-0001-7966-3509

Funding

Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer diseaseR01AG068183 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$6.7M
Preclinical Alzheimer Disease and DrivingR01AG056466 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2017 to 2021
$5.9M
The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older AdultsR01AG067428 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$4.0M
NIA NIH HHS R01 AG056466NIA NIH HHS R01 AG067428NIA NIH HHS R01 AG068183
6 · The paper itself

Abstract

BackgroundThe aging United States population is expected to significantly increase by 2050, along with Alzheimer's disease (AD), a leading cause of cognitive impairment among older adults. AD is associated with declines in driving abilities and compromised safety, yet early detection remains challenging. Plasma biomarkers like ptau

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAutomobile DrivingPeptide Fragmentstau ProteinsAgedAged, 80 and overBiomarkersFemaleHumansLongitudinal StudiesMaleAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseasedrivinglongitudinal studiesolder adultsplasma

Identifiers

PMID40776790
PMCPMC12747066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.